The German Center for Neurodegenerative Diseases (DZNE) is a world-leading internationally oriented research center, committed to discovering new approaches to prevent and treat neurodegenerative diseases. To this end, researchers at ten DZNE sites across Germany pursue a translational and interdisciplinary strategy comprising five interconnected areas: fundamental research, clinical research, health care research, population health science, and systems medicine.
Role within NeuroCOV
By virtue of its expertise in translational neuroscience, the DZNE unit coordinates the clinical evaluation and patient recruitment for the German NeuroCOV cohort, as a joint effort of the Bonn and Berlin DZNE sites. Furthermore, the unit will genotype NeuroCOV cohorts with the aim to stratify patients based on their genetic susceptibilities, driving the selection of a representative subset of samples for downstream mechanistic analyses. In light of the expertise in single-cell immunomics and supported by the established PRECISE sequencing platform for genomics and epigenomics, the DZNE is further engaged in the multi-omic analysis of sampled peripheral blood (PB) at single-cell resolution. Transcriptome and protein marker profiles of blood-derived mononuclear cells will be investigated to achieve the systematic modelling of NeuroCOVID dynamics at the peripheral level, up to the computation-driven identification of novel therapeutic options.